Phosphorylation

The phosphorylation reaction is an important reaction in organic synthesis, especially in DNA or RNA synthesis where nucleotides are made by adding phosphate groups to nucleosides. Various reagents and methods of phosphorylation have been developed. For example, the phosphorylation methods include the DCC method by Khorana et al., the phosphotriester method and the phosphite method by Letsinger et al. and the amidite method by Caruthers et al. etc. They are utilized depending on each purpose. This section below shows the typical reagents employed for phosphorylation.

C0978 C0978 B3125 B3125 C1210 C1210
C1215 C1215 C1250 C1250 C0976 C0976
C0977 C0977 C2228 C2228 D2624 D2624
D0624 D0624 D0764 D0764 D1059 D1059
D2883 D2883 M0905 M0905 M0904 M0904
P0209 P0209 P1223 P1223
C0978 Barium 2-Cyanoethylphosphate Hydrate [Phosphorylating Agent]
B3125 3H-1,2-Benzodithiol-3-one 1,1-Dioxide
C1210 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one
C1215 2-Chloro-1,3,2-dioxaphospholane
C1250 2-Chloro-2-oxo-1,3,2-dioxaphospholane
C0976 2-Chlorophenyl Phosphorodichloridate [Phosphorylating Agent]
C0977 4-Chlorophenyl Phosphorodichloridate [Phosphorylating Agent]
C2228 2-Cyanoethyl N,N,N',N'-Tetraisopropylphosphordiamidite
D2624 Dibenzyl N,N-Diisopropylphosphoramidite
D0624 Diethyl Chlorothiophosphate
D0764 Dimethyl Chlorothiophosphate
D1059 Diphenyl Chlorophosphate
D2883 Diphosphoryl Chloride
M0905 Methyl Dichlorophosphite [Phosphitylating Agent]
M0904 Methyl Phosphorodichloridate
P0209 Phenyl Dichlorophosphate
P1223 Tetrabenzyl Pyrophosphate
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