Structure
| TCI Product No. : | C1383 | ||||||||||||||
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| Stock Status : |
Status at 03:00 a.m. on 03 Sep 2010 * Items available from stock in Japan will be delivered in 10 business days |
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| Purity / Analysis Method : | |||||||||||||||
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| M.F. / M.W. : | C55H46OP3Rh=918.78 | ||||||||||||||
| CAS Number : | 17185-29-4 | ||||||||||||||
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| MDL Number : | MFCD00151644 | ||||||||||||||
Rh(I)-catalyzed synthesis of indoles through the amino-Claisen rearrangement of N-propargylanilines Typical procedure: Under an argon atmosphere, to a solution of carbonyltris(triphenylphosphine)rhodium(I) hydride (16 micro-mol) in 1,1,1,3,3,3-hexafluoro-2-propanol (1 mL) is added N-2-butynyl-N-benzyl-4-methoxyaniline (0.4 mmol) in 1,1,1,3,3,3-hexafluoro-2-propanol (1.5 mL) at an ambient temperature, and the mixture is refluxed until the consumption of the substrate by TLC analysis. The mixture is diluted with ether and filtered through a Celite pad. After concentration of the filtrate to dryness, purification by silica gel chromatography (hexane/AcOEt = 25:1) gives the corresponding indole in 99% yield. |
| Merck Index(14) : | 9758 |
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| F & F : | 7, 53 |
| EC Number : | 241-230-3 |
| UNNo. : | 2811 |
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| Class : | 6.1 |
| PG : | III |
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X(n) harmful |
| Moisture sensitive | |
| Air sensitive |
| R20/21/22 : | Harmful by inhalation, in contact with skin and if swallowed. |
| S22 : | Do not breathe dust. |
| S36/37 : | Wear suitable protective clothing and gloves. |
| Related Categories : |
Structure of Chemicals
Classes of Metal Compounds
Transition Metal Compounds
Rh (Rhodium) Compounds
Synthetic Organic Chemistry Catalysts for Organic Synthesis Homogeneous Catalysts Metal Complexes Synthetic Organic Chemistry Catalysts for Organic Synthesis Homogeneous Catalysts Rhodium |
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